Facilitating pharmacometric workflow with the metrumrg package for R
نویسندگان
چکیده
metrumrg is an R package that facilitates workflow for the discipline of pharmacometrics. Support is provided for data preparation, modeling, simulation, diagnostics, and reporting. Existing tools and techniques are emphasized where available; original solutions are provided for otherwise unmet needs. In particular, metrumrg implements an R interface for the NONMEM(®) modeling software, optionally run in a distributed computing environment. The paradigm allows start-to-finish analyses in a single scripting language. Emphasis on text-based formats promotes traceability of results.
منابع مشابه
Interactive Pharmacometric Applications Using R and the Shiny Package
Interactive applications, developed using Shiny for the R programming language, have the potential to revolutionize the sharing and communication of pharmacometric model simulations. Shiny allows customization of the application's user-interface to provide an elegant environment for displaying user-input controls and simulation output-where the latter simultaneously updates with changing input....
متن کاملA Tutorial on RxODE: Simulating Differential Equation Pharmacometric Models in R
This tutorial presents the application of an R package, RxODE, that facilitates quick, efficient simulations of ordinary differential equation models completely within R. Its application is illustrated through simulation of design decision effects on an adaptive dosing regimen. The package provides an efficient, versatile way to specify dosing scenarios and to perform simulation with variabilit...
متن کاملThoughtflow: Standards and Tools for Provenance Capture and Workflow Definition to Support Model‐Informed Drug Discovery and Development
Pharmacometric analyses are complex and multifactorial. It is essential to check, track, and document the vast amounts of data and metadata that are generated during these analyses (and the relationships between them) in order to comply with regulations, support quality control, auditing, and reporting. It is, however, challenging, tedious, error-prone, and time-consuming, and diverts pharmacom...
متن کاملApplication of ggplot2 to Pharmacometric Graphics
Visualization is a powerful mechanism for extracting information from data. ggplot2 is a contributed visualization package in the R programming language, which creates publication-quality statistical graphics in an efficient, elegant, and systematic manner. This article summarizes key features of the package with examples from pharmacometrics and pointers to available resources for learning ggp...
متن کاملAnaquin - Vignette
This vignette is written for R-usage. However, Anaquin is a framework covering the entire RNA-Seq workflow; reads alignment, transcriptome assembly, gene expression and differential analysis, etc. Consequently, the R-package (and it’s documentation) is a subset of the overall Anaquin framework. We also distribute a workflow guide with this vignette on how Anaquin can be integrated with a bioinf...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Computer methods and programs in biomedicine
دوره 109 1 شماره
صفحات -
تاریخ انتشار 2013